Lipid Nanoparticle design
We provide Ionizable lipid (IL) library screening and transfection efficiency prediction using AI/ML models
Context
Lipid Nanoparticles (LNPs) for mRNA delivery
Lipid nanoparticles (LNPs) have emerged as a powerful non-viral delivery platform, revolutionizing nucleic acid therapeutics, from mRNA vaccines to next-generation gene therapies. Their effectiveness hinges on precise design and formulation, which influence biophysical properties such as stability, biodistribution, and cellular uptake. With a data-driven approach, we enable tailored LNP formulations to meet the specific demands of cutting-edge biopharma innovations.
Challenges
Challenges in Lipid Nanoparticle (LNP) development
• Lipid Design & Formulation: Optimizing lipid composition for stability
and delivery
• Tissue-Targeted Delivery: Enhancing specificity, minimizing off-target
effects, with ligand-functionalized LNPs
• Immunogenicity: Reducing inflammatory responses and anti-PEG
immunity
• Extrahepatic Delivery (IV Administration): Overcoming liver-dominant
uptake for tissue-specific biodistribution
Aganitha’s Solution
Ionizable lipid library screening using AI/ML models trained on experimental data
🔹 Ionizable lipid (IL) library screening and transfection efficiency prediction using AI/ML models
🔹 Validation of the predicted ionizable lipids through Molecular Dynamics (MD) simulations
🔹 LNP characterization using MD simulations
LNP-endosomoal membrane fusion
Surface charge distribution
