Lipid Nanoparticle design

Lipid nanoparticles (LNPs) have emerged as a powerful non-viral delivery platform, revolutionizing nucleic acid therapeutics—from mRNA vaccines to next-generation gene therapies. Their effectiveness hinges on precise design and formulation, which dictate critical biophysical properties such as stability, biodistribution, and cellular uptake. However, optimizing LNPs for therapeutic success requires addressing key challenges: engineering ionizable lipids and optimizing composition for stability and efficient delivery, enhancing tissue-targeted specificity while minimizing off-target effects, and mitigating immunogenicity to reduce inflammatory responses and anti-PEG immunity. With a data-driven approach, we develop tailored LNP formulations that meet the specific demands of cutting-edge biopharma innovations.