Target and Biomarker Research

De-risking & accelerating drug discovery with
precision target and biomarker identification, assessment & validation

Source: Mosser et al., Nature 2023

Bridging the Gap: The Role of Target and Biomarker Research in Biopharma Innovation

Biopharma wins come from hard-fought battles. Out of 7,500 diseases with known molecular basis, only 500 have effective treatments. Translation of lab findings to approved drugs continues to be highly risky and costly. Key bottleneck is in incomplete understanding of human disease biology.

Advancements in genomics, proteomics, transcriptomics as well as organoids research enable de-risking with better target identification and patient stratification. However, the expertise needed to distill molecular data to insights remains in short supply.

Aganitha’s Disease Biomarker and Target Insights Platform & Services (DBTIPS™) triage & integrate signals from multi-omics, real world evidence & market intelligence to enable effective target & biomarker identification, assessment & validation.

Key Solution Areas

Solution Area

Disease Research

Aganitha DBTIPSTM, DISTILLTM & NGS DataWorksTM provide comprehensive solutions for disease research, accelerating R&D journeys from available genomic evidence, multi-omics studies, past clinical trials,  real world data (RWD), published literature and knowledge bases, to translatable understanding of molecular and biological processes underlying diseases.

AI generated disease dossiers

Aganitha DBTIPSTM auto-generates disease dossiers, collating latest literature & data on disease pathways, genomic associations, diagnostic biomarkers, targets in trials, animal and organoid models, to kick-start investigations for new indications.

Data to insights with AI automation

Aganitha DISTILLTM tames the complexity of single-cell and spatial omics data analysis with AI powered generation & triaging of insights from cross-species, public and proprietary studies, drastically cutting the time needed to go from data to insights. 

Robust portable analysis pipelines for biobank-scale NGS data

Aganitha NGS DataWorksTM pipelines provide a robust no-code solution for analysis of biobank-scale multi-omics datasets with infra-as-code, dynamic cloud scaling, HPC, and long-read sequencing support.

Indication expansion & drug repurposing solutions

Aganitha provides consulting services to generate, assess and validate hypotheses for indication expansion & drug repurposing, with AI powered analysis of RWD, pre-clinical and clinical data, genomic associations, functional genomics insights, mechanism of action (MoA) pathways and knowledge graphs (KG).

Solution Area

Target and Biomarker Research

Aganitha DBTIPSTM auto-collates and analyses evidence, market intelligence and target properties to enable comprehensive target and biomarker identification, assessment & validation.

AI generated target & biomarker dossiers

Aganitha DBTIPSTM auto-generates target and biomarker dossiers, collating latest literature & data on:

  • Target/biomarker roles in disease pathways as evidenced by human, model organism or organoid studies,
  • Genomic evidence linking target/biomarker to disease phenotypes
  • Market intelligence covering prior clinical studies & opinion from KOLs
  • Structural and functional  data enabling target tractability assessments
  • Safety analyses using real world data, methods from evolutionary biology,  structural biology & genomics, and perturbation study results

Network biology analyses

Aganitha provides consulting services to build focused knowledge graphs (KG), gene regulatory networks (GRN), logical models and multi-modal deep neural nets to coalesce and analyze evidence from diverse assays and relevant databases, generate novel targeting opportunities and validate proposed interventions.

Scorecards for target selection

Aganitha DBTIPSTM  generates comprehensive scorecards for assessing multiple targets under consideration and make evidence grounded go/no-go decisions.

Highlights

Key Components & Strengths

Genomics

Leveraging advanced gene mapping and genomic insights, researchers can identify high-confidence targets, significantly improving drug discovery success rates.

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Transcriptomics

Aganitha’s DISTILLTM pipeline provides insights into gene expression patterns, helping identify disease-relevant targets and biomarkers, thereby guiding precise and effective drug discovery efforts.

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Proteomics

Aganitha proteomics pipelines  enable analysis of advanced mass spectrometry and affinity based proteomic study data, for rapid and accurate biomarker identification.

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Organoid Research

Aganitha AI solutions for organoid studies enable model development, validation, disease modeling, drug efficacy testing, and toxicity evaluation.

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Omics Data Pipelines

Robust no-code solutions for omics analysis, e.g., GWAS, differential gene expression analysis, spatial transcriptomics analysis, protein/metabolite identification and more. 

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