Solutions overview
Transforming Drug Discovery Through Precision Target and Disease Biomarker Analysis
Target analysis is the foundation of effective drug discovery. In an era of complex, multifactorial diseases, finding truly impactful targets is a high-stakes task. Though the idea seems simple—find a disease-linked target, then design a therapeutic around it—the reality is far more complex.
A major challenge in drug discovery is validating targets early, as many drugs fail in clinical trials due to misaligned hypotheses about how a target influences disease progression in specific patient populations. Multi-omics technologies are transforming this process by decoding complex biological interactions to identify disease-relevant targets. These technologies reveal genetic mutations and biomarkers driving disease, decode protein structures and interactions for better drug design, map gene expression changes across disease stages, and uncover shifts in cellular metabolism linked to disease. Together, they provide a multi-dimensional view of disease, offering critical insights for precision drug discovery.
Insufficient analysis often leads to costly trial failures and lower drug approval rates. Together, these omics layers empower researchers to pinpoint high-confidence targets with unprecedented accuracy. By investing in robust target analysis and validation studies upfront, we can reduce development costs and increase the success rate of new therapies.
Target Identification
An in-depth understanding of the underlying disease mechanisms, as well as the application of advanced technologies and analytical methods to discover therapeutic targets.
Target Assessment
Our comprehensive Target dossiers integrate structural, functional, and safety data with advanced information retrieval technologies and scientific expertise, creating a powerful toolbox for target assessment and optimization. Leveraging statistics and bioinformatics, these dossiers illuminate disease mechanisms and phenotypes, guiding informed, data-driven decisions on target selection and validation for therapeutic development.
Target Validation
Experimental validation is key, often using gene knockout or overexpression models to demonstrate the target’s role in disease pathways. Functional assays, such as RNA interference or CRISPR-Cas9, help confirm the target’s biological relevance.
Target Elucidation
Understanding the target’s role in disease guides the design of effective therapeutic strategies. In silico methods predict both covalent and non-covalent binding interactions with small molecules. Epitope mapping is used to identify regions that are important for immune modulation or antibody development.
Aganitha's Solutions
We have built strong core capabilities and platforms to help biopharma companies by delivering tailor-made target assessment dossiers.
